gene_symbol
SOCS1
hgnc_id
HGNC:19383
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SOCS1 is knocked out in the infused TILs to enhance their function; these TILs then kill tumor cells they recognize via TCR-mediated cytotoxicity (perforin/granzyme, Fas–FasL). SOCS1-expressing cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CRISPR-Cas9 knockout in autologous TILs to relieve negative regulation of cytokine/JAK-STAT signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06237881
disease_id_num_tar_ref
4291
drug_id_num_tar_ref
11608