gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous SOCS1-inactivated TILs recognize the patient-specific neoantigen–HLA complex via their endogenous TCR and directly kill target cells through perforin/granzyme-mediated cytolysis and death-receptor pathways (e.g., Fas–FasL), with enhanced activity from boosted JAK-STAT signaling.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized by endogenous TCRs in a polyclonal TIL repertoire; predominantly HLA class I–restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06237881
disease_id_num_tar_ref
4291
drug_id_num_tar_ref
11608