gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous SOCS1-knockout TILs recognize the tumor-associated peptide–HLA complex via their native TCRs and directly lyse target cells through cytotoxic T-cell mechanisms (perforin/granzyme and Fas–FasL apoptosis), with enhanced activity from SOCS1 inactivation.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
May include shared TAAs; specificities vary by patient and tumor type; recognized by endogenous TCRs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06237881
disease_id_num_tar_ref
4291
drug_id_num_tar_ref
11608