gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells and its IgG1 Fc engages CD16 (FcγRIIIa) on NK cells, triggering antibody-dependent cellular cytotoxicity (ADCC) that kills PD-L1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks PD-L1 interaction with PD-1 (PDCD1) and CD80 (B7.1)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06242522
disease_id_num_tar_ref
4292
drug_id_num_tar_ref
11612