gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells and recruits FcγR-bearing effector cells (e.g., NK cells) to mediate ADCC; it also blocks PD-1/PD-L1 to restore CTL killing (indirect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks PD-L1 interactions with PD-1 and CD80 (B7-1); IgG1 Fc can mediate ADCC against PD-L1-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05327686
disease_id_num_tar_ref
4296
drug_id_num_tar_ref
11618