gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds EGFR on tumor cells and engages Fcγ receptors on immune effector cells to trigger ADCC (and potentially CDC), leading to lysis of EGFR-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III) to block ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05063552
disease_id_num_tar_ref
4302
drug_id_num_tar_ref
11640