gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the patient-specific mutated neoantigen peptide presented by HLA on target cells and induce HLA-restricted killing via perforin/granzyme–mediated apoptosis (and related cytotoxic pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Tumor-specific somatic mutation–derived peptide recognized as a peptide–HLA complex on tumor cells (typically class I; allele-specific).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04102436
disease_id_num_tar_ref
4307
drug_id_num_tar_ref
11656