gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered TCR T cells kill only cells presenting the specific mutated peptide bound to the patient’s HLA allele via TCR recognition and perforin/granzyme cytotoxicity; expression of the HLA molecule alone does not trigger killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element engaged by the TCR as part of the peptide–HLA complex (e.g., HLA class I allele such as HLA-A/B/C; exact allele is patient-specific).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04102436
disease_id_num_tar_ref
4307
drug_id_num_tar_ref
11656