gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DC1 vaccine primes/activates HER2/HER3-specific T cells that recognize HER2 peptide–MHC on tumor cells and kill them via perforin/granzyme (and Fas–FasL) cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Presented via MHC I/II by autologous DC1 to T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05809752
disease_id_num_tar_ref
4311
drug_id_num_tar_ref
11666