gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC1 vaccine presents HER3 peptides to T cells, priming HER3-specific CD8+ CTLs that recognize HER3 peptide–MHC on tumor cells and kill them via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Presented via MHC I/II by autologous DC1 to T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05809752
disease_id_num_tar_ref
4311
drug_id_num_tar_ref
11666