gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SHR-A1811 binds HER2 on tumor cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor that stabilizes topo I–DNA complexes, causing DNA breaks, replication arrest, and apoptosis; payload can diffuse for bystander killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (camptothecin derivative, rezetecan) inhibits TOP1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06430437
disease_id_num_tar_ref
4313
drug_id_num_tar_ref
11668