gene_symbol
NECTIN1
hgnc_id
HGNC:9706
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HSV-1 uses Nectin-1 (CD111) as an entry receptor (gD binding); after entry the engineered virus selectively replicates in tumor cells, causing lytic oncolysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HSV-1 gD entry receptor on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06080984
disease_id_num_tar_ref
4324
drug_id_num_tar_ref
11709