gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Killing requires engineered TCR-T cells to recognize the KRAS G12V peptide presented by HLA-A*11:01 and then lyse the cell via perforin/granzyme; HLA-A*11:01 expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element presenting the KRAS G12V peptide to the engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06484556
disease_id_num_tar_ref
378
drug_id_num_tar_ref
1063