gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP-2, is internalized, and releases a topoisomerase I inhibitor payload that causes DNA damage, leading to apoptosis/tumor cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface antigen targeted by ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06519370
disease_id_num_tar_ref
4334
drug_id_num_tar_ref
11738