gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP-2 on tumor cells and is internalized; its released topoisomerase I inhibitor poisons DNA topoisomerase I to cause DNA damage and cell death. DNA topoisomerase I is not the antibody’s binding target.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload enzyme target (topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06519370
disease_id_num_tar_ref
4334
drug_id_num_tar_ref
11738