gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-TROP2 ADC binds TROP2, is internalized (and/or cleaved extracellularly), releasing the topoisomerase I inhibitor tirumotecan that causes DNA damage, replication arrest, and apoptosis; bystander killing can also occur.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface tumor-associated antigen (TAA)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06459180
disease_id_num_tar_ref
4338
drug_id_num_tar_ref
11746