gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets TROP2 (not topoisomerase I) for delivery; after binding TROP2 and internalization or extracellular cleavage, tirumotecan is released and inhibits DNA topoisomerase I, causing DNA damage and apoptosis in TROP2-positive cells (with a bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload target (tirumotecan; camptothecin derivative)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06459180
disease_id_num_tar_ref
4338
drug_id_num_tar_ref
11746