gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize KRAS G12D peptide presented by HLA-A*11:01 on tumor cells and directly induce cytotoxic T-lymphocyte killing (perforin/granzyme-mediated apoptosis, Fas–FasL).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class I complex target; HLA-A*11:01 restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06484556
disease_id_num_tar_ref
378
drug_id_num_tar_ref
1064