gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and induces complement-dependent cytotoxicity (CDC), Fc-mediated ADCC by NK cells, ADCP by macrophages, and can trigger apoptosis upon crosslinking.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ectoenzyme (ADP-ribosyl cyclase/cADPR hydrolase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05289687
disease_id_num_tar_ref
4344
drug_id_num_tar_ref
11765