gene_symbol
CD4
hgnc_id
HGNC:1678
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD4 CAR T cells bind CD4 on target cells, become activated, and kill via perforin/granzyme-mediated cytolysis (and possibly Fas–FasL apoptosis), leading to depletion of CD4+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen on AML blasts and normal CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06197672
disease_id_num_tar_ref
4356
drug_id_num_tar_ref
11796