gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds Trop-2, is internalized, and releases SN-38, which inhibits topoisomerase I causing DNA damage and apoptosis (with potential bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; antibody moiety of ADC binds and is internalized
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06329869
disease_id_num_tar_ref
379
drug_id_num_tar_ref
1065