gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AMG 701 binds CD3 on T cells to recruit and activate them; the T cells then kill BCMA-positive tumor cells (perforin/granzyme). CD3+ T cells themselves are not targeted for lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target is the CD3 complex; binding typically to epsilon chain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04998747
disease_id_num_tar_ref
4357
drug_id_num_tar_ref
11797