gene_symbol
IDO1
hgnc_id
HGNC:6059
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine induces IDO1-specific CD8+ T cells (with CD4+ help) that recognize IDO1 peptides on MHC and kill IDO1-expressing cells via T-cell cytotoxicity (perforin/granzyme/Fas).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular enzyme; recognition via HLA-presented IDO1-derived peptides on tumor/APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05280314
disease_id_num_tar_ref
4358
drug_id_num_tar_ref
11798