gene_symbol
ITGAL
hgnc_id
HGNC:6148
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Polyclonal IgG in ATLG binds CD11a on T cells and triggers complement-dependent cytotoxicity and Fc-mediated ADCC, also inducing apoptosis of the bound cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
heterodimer partner: ITGB2 (CD18)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06525519
disease_id_num_tar_ref
4359
drug_id_num_tar_ref
11801