gene_symbol
ITGB2
hgnc_id
HGNC:6155
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Polyclonal anti–T-cell IgG binds CD18 (LFA-1 beta) on T cells and induces complement-dependent cytotoxicity and Fc-mediated ADCC, leading to apoptotic/lytic depletion of the bound cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
heterodimer partner: ITGAL (CD11a)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06525519
disease_id_num_tar_ref
4359
drug_id_num_tar_ref
11801