gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds NECTIN-4, is internalized, and releases MMAE, which inhibits β-tubulin polymerization causing G2/M arrest and apoptosis. β-tubulin is the intracellular payload target, not the antigen directing cell selectivity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cytotoxic payload (MMAE) binds the vinca domain on β-tubulin to inhibit microtubule polymerization; affects multiple β-tubulin isotypes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06011954
disease_id_num_tar_ref
4387
drug_id_num_tar_ref
11877