gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CLDN18.2 on target cells, is internalized, and releases MMAE via a cleavable linker; MMAE disrupts microtubules, causing G2/M arrest and apoptosis of CLDN18.2-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18 (stomach-specific tight junction protein)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06219941
disease_id_num_tar_ref
4393
drug_id_num_tar_ref
11896