gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages Fcγ receptors on NK cells to mediate ADCC against EGFR-expressing cells (and can also activate complement-dependent cytotoxicity); signaling blockade is antiproliferative.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of EGFR to block ligand binding and receptor dimerization; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05756153
disease_id_num_tar_ref
4400
drug_id_num_tar_ref
11917