gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible inhibition of mutant EGFR (including T790M) suppresses EGFR signaling (e.g., MAPK/PI3K-AKT), causing growth arrest and apoptosis of EGFR-mutant cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent inhibitor at Cys797
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06498986
disease_id_num_tar_ref
4402
drug_id_num_tar_ref
11921