gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-EGFR antibody opsonizes EGFR+ cells; Fcγ receptor–bearing effector cells (e.g., NK cells) kill via ADCC (and possibly CDC). EGFR signaling blockade mainly inhibits proliferation; cytotoxicity is immune-mediated.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular ligand-binding domain, blocking EGF/TGF-α interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06422156
disease_id_num_tar_ref
386
drug_id_num_tar_ref
1084