gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 on tumor cells, is internalized, and releases MMAE, which inhibits microtubule polymerization causing G2/M arrest and apoptosis; can also induce ADCC and bystander killing.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody component of ADC binds HER2 receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05911295
disease_id_num_tar_ref
4405
drug_id_num_tar_ref
11924