gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds PSMA on tumor cells, is internalized, and releases amberstatin payload that inhibits tubulin polymerization, causing G2/M arrest and apoptotic cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen; internalizes upon antibody binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04662580
disease_id_num_tar_ref
4407
drug_id_num_tar_ref
11933