gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ARX517 binds PSMA on tumor cells; after internalization, its AS269 payload binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis. Beta-tubulin is not the targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload (amberstatin/AS269) binds the vinca site to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04662580
disease_id_num_tar_ref
4407
drug_id_num_tar_ref
11933