gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16 on PD-L1 t-haNK binds the IgG1 Fc of therapeutic antibodies (e.g., cetuximab) coating tumor cells, triggering NK-mediated ADCC that kills the antibody-opsonized, antigen-positive tumor cells; the IgG1 Fc itself is not a cellular target killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding via high-affinity FcγRIIIa (CD16a) on engineered NK cells to mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06239220
disease_id_num_tar_ref
4417
drug_id_num_tar_ref
11961