gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab opsonizes EGFR-expressing cells and recruits immune effectors via its IgG1 Fc to trigger NK cell–mediated ADCC and complement-dependent cytotoxicity, leading to lysis of EGFR+ cells (while also blocking EGFR signaling).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain III to block ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06239220
disease_id_num_tar_ref
4417
drug_id_num_tar_ref
11962