gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells; its Fc engages CD16a on NK cells to trigger ADCC against EGFR+ cells. CD16a-expressing cells are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc-mediated engagement to trigger ADCC; higher affinity for V158 allele
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06239220
disease_id_num_tar_ref
4417
drug_id_num_tar_ref
11962