gene_symbol
PDCD1
hgnc_id
HGNC:8760
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PD-1 is blocked on T cells to relieve inhibition, enhancing CAR T activity; killing is directed at mesothelin-positive cells via CAR-mediated cytolysis (perforin/granzyme), not at PD-1–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
local anti-PD-1 checkpoint blockade to inhibit PD-1/PD-L1 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05944185
disease_id_num_tar_ref
4418
drug_id_num_tar_ref
11964