gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and kills via enhanced Fc gamma RIIIa (CD16a)-mediated ADCC by NK cells and antibody-dependent phagocytosis, plus direct caspase-independent cell death; complement involvement is minimal.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II binding to extracellular domain; induces direct cell death with enhanced ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06415708
disease_id_num_tar_ref
4423
drug_id_num_tar_ref
11971