gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets Trop-2 for delivery; once internalized, the SN-38 payload inhibits DNA topoisomerase I, causing DNA damage, cell-cycle arrest, and apoptosis (with possible bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of SN-38 payload; stabilization of TOP1-DNA complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06486441
disease_id_num_tar_ref
387
drug_id_num_tar_ref
1088