gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
PSMA-617 binds PSMA on tumor cells, is internalized, and 177Lu beta emissions cause DNA double-strand breaks (with crossfire to nearby cells), leading to cell death.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Internalizing cell-surface glutamate carboxypeptidase II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06388369
disease_id_num_tar_ref
4433
drug_id_num_tar_ref
11993