gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-BCMA CAR T cells recognize BCMA on target cells via the CAR, activate (4-1BB/CD3ΞΆ), and kill BCMA+ cells through cytotoxic effector functions, primarily perforin/granzyme-mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound BCMA on plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06056102
disease_id_num_tar_ref
4437
drug_id_num_tar_ref
12000