gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific binds CD3 on T cells to recruit/activate them and bridge them to tumor-antigen–positive cells; T cells then kill the tumor cells via perforin/granzyme, not the CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3-binding arm on T cells for T-cell recruitment/activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06412471
disease_id_num_tar_ref
389
drug_id_num_tar_ref
1093