gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc mediates ADCC by NK cells (and other FcγR+ effectors) against PD-L1–expressing cells; checkpoint blockade also restores T-cell killing (indirect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Checkpoint ligand (also known as B7-H1); cell-surface protein on tumor and immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06228066
disease_id_num_tar_ref
4449
drug_id_num_tar_ref
12031