gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on the cell surface and its IgG1 Fc recruits immune effectors to mediate ADCC and complement-dependent cytotoxicity, killing EGFR-expressing cells (used here to ablate EGFRt-tagged CAR T cells).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05672147
disease_id_num_tar_ref
4450
drug_id_num_tar_ref
12033