gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds the EGFRt tag and, via its Fc domain, engages immune effectors to kill tagged cells through ADCC and complement-mediated lysis (and phagocytosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
engineered truncated form used for CAR T elimination
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05672147
disease_id_num_tar_ref
4450
drug_id_num_tar_ref
12033