gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages FcγRIIIa (CD16A) on NK cells/macrophages to drive ADCC/ADCP that kills CD20+ B cells. CD16A+ cells act as effectors and are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector interaction; enhanced affinity due to glycoengineering (reduced fucosylation)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06592170
disease_id_num_tar_ref
4461
drug_id_num_tar_ref
12055