gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab opsonizes EGFR+ cells and engages FcγR-bearing effector cells (e.g., NK cells) to mediate ADCC (with some CDC possible); EGFR signaling blockade is mainly cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III); blocks ligand binding and receptor dimerization; inhibits downstream signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05774964
disease_id_num_tar_ref
4464
drug_id_num_tar_ref
12064