gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells; its IgG1 Fc engages CD16a on NK cells to trigger ADCC, killing EGFR+ cells. CD16a-expressing cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement mediates ADCC; affinity influenced by FCGR3A V158F polymorphism
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05774964
disease_id_num_tar_ref
4464
drug_id_num_tar_ref
12064