gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds BCMA, is internalized, and delivers MMAF to inhibit tubulin polymerization, causing G2/M arrest and apoptosis; afucosylated Fc can also trigger ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04876248
disease_id_num_tar_ref
4465
drug_id_num_tar_ref
12068