gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-EGFR mAb engages FcγR-bearing effector cells to kill EGFR+ cells via ADCC (and possibly CDC); EGFR signaling blockade is antiproliferative.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocking ligand binding; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06561763
disease_id_num_tar_ref
394
drug_id_num_tar_ref
1108